NFL Blitz 2000 became the first time the NFL Blitz sequence had crossed over onto the PC, Playstation, and Dreamcast platforms. It became previously featured exclusively on the Arcade and Nintendo owned console platforms comparable to the Nintendo Sixty four and Sport Boy Color.
- In episode ten of Button Mashing, Jeff proclaimed that he and his life long rival Vince had been the great NFL Blitz avid gamers on the earth. They had an intense fight but within the halt Jeff became the victor.
- The Denver Broncos have the best stats of any crew within the sport.